Current and Future Views in G-Quadruplex Secondary Structure as an Anti-Cancer Target
نویسندگان
چکیده
منابع مشابه
G-quadruplex structure of an anti-proliferative DNA sequence
AGRO100 (also known as AS1411) is a G-rich oligonucleotide that has long been established as a potent anti-cancer aptamer. However, the structure of AGRO100 remained unresolved, due to the co-existence of multiple different G-quadruplex conformations. We identified a DNA sequence named AT11, derived from AGRO100, which formed a single major G-quadruplex conformation and exhibited a similar anti...
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A curated library of circular dichroism spectra of 23 G-quadruplexes of known structure was built and analyzed. The goal of this study was to use this reference library to develop an algorithm to derive quantitative estimates of the secondary structure content of quadruplexes from their experimental CD spectra. Principal component analysis and singular value decomposition were used to character...
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ژورنال
عنوان ژورنال: Journal of Physical Chemistry & Biophysics
سال: 2013
ISSN: 2161-0398
DOI: 10.4172/2161-0398.1000e117